Astragalus polysaccharide protects photoreceptors from hypoxic injury via a multi-mechanism network involving mitochondrial stabilization and enhanced autophagy.
BACKGROUND Retinal hypoxia contributes to photoreceptor death in multiple blinding diseases. Astragalus polysaccharide (APS) exhibits broad bioactivity, but its protection against hypoxic photoreceptor injury remains unclear. OBJECTIVE This study evaluated the cytoprotective effect and mechanism of APS in hypoxic 661...