Open access
Sep 2026
TRPML1 inhibitor ML-SI1 suppresses prostate cancer through dual regulation of androgen receptor and polyamine metabolism
Prostate cancer (PCa) is the second leading cause of cancer-related death in men worldwide, with metastasis and drug resistance representing major drivers of mortality. Transient receptor potential mucolipin 1 (TRPML1), a member of the transient receptor potential channel superfamily, is associated with several mal...
Jiong-Zheng Li, Ji-Peng Ding, Hong-Fei Wei et al.
· Frontiers in Medicine · 0 citations