Author

Jing Li

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Clinical trial Open access Sep 2026

Pharmacokinetics, Immunogenicity, and Safety of a Modified YTE Antibody in Healthy Adults

Abstract REGN17092, a fully human immunoglobulin (Ig) G1 antibody with M252Y/S254T/T256E (YTE) modification in the Fc portion, was assessed in a first‐in‐human study (ClinicalTrials.gov, NCT05923424). REGN17092 was designed to target the severe acute respiratory coronavirus 2 (SARS‐CoV‐2) S protein. However, due to the...

María Rosario, J. D. de Hoon, F. Isa et al. · Clinical pharmacology in dru... · 0 citations

Open access Oct 2026

Stimulator of Interferon Genes (STING) Agonist-Loaded Copper-Based Nanoparticles for B7-H3 Blockade-Enhanced Chemodynamic-Immunotherapy of Ovarian Cancer

Introduction Ovarian cancer remains difficult to treat because of limited tumor immunogenicity, poor cytotoxic T-cell infiltration, and a strongly immunosuppressive tumor microenvironment. Methods Characterization, in vitro cell experiments, and tumor mouse model was performed. Results Here, we developed an anti-B7-H3...

Yu-Gao Jin, Jing Li, Qi Li et al. · International Journal of Nan... · 0 citations