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Author

Jing Liu

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Jul 2026

Deep Mutational Scanning of the GPCR Rhodopsin Reveals Pleiotropic Mutational Effects and Their Roles in Modulating Light Sensitivity

A systematic study of pleiotropic effects within the receptor responsible for dim-light vision in vertebrates is presented, revealing how light sensitivity can be mediated through differential conformational states of its chromophore and revealing a role for biophysical pleiotropy in shaping the sensory capabilities of...

Steven K. Chen, Jing Liu, B. Chang · 0 citations

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