Author

Jing Luo

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Open access Sep 2026

IgE drives osteoclastogenesis via binding with FcεRII in sparganosis-induced bone destruction

Progressive multi-vertebral osteolysis, frequently misdiagnosed as malignancy or tuberculosis, can also be driven by a previously unrecognized infectious trigger. Here we demonstrate that sparganosis induces pronounced IgE-dependent osteoclastogenesis and severe bone destruction. Single-cell RNA analysis of periphera...

Yong-Ai Li, T. Meng, Ying-Qi Wang et al. · Cell Death & Disease · 0 citations

Sep 2026

Association of clinical-immunologic clusters and anti-RNP/Ro52 antibody profiles with prognostic trajectories in primary Sjögren's disease.

OBJECTIVE To delineate the prognostic architecture of primary Sjögren's disease (pSjD) through an integrated analysis of clinical-immunologic clusters and anti-RNP/anti-Ro52 antibody profiles. METHODS This ambispective cohort study enrolled 1293 patients with pSjD from China-Japan Friendship Hospital (2013-2023). Uns...

Bo Tang, Yan Zhang, Xin-Bo Yu et al. · Journal of Autoimmunity · 0 citations

Open access Jul 2026

Single-cell expression quantitative trait loci-based Mendelian randomization identifies MAN1A2 in naive CD4+ T cells as a candidate therapeutic target for osteoarthritis.

BACKGROUND Osteoarthritis (OA) is a leading cause of chronic pain and disability worldwide, with growing evidence implicating immune dysregulation in its pathogenesis. However, the specific peripheral immune cell populations contributing causally to OA risk remain poorly characterized. METHODS We performed a multi-st...

Xuanyi Zhou, Fangyu Liu, Yan Zhang et al. · Experimental Gerontology · 0 citations