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Open access Aug 2026

Targeting tumour-neuron synapses with intracavitary RNA delivery prevents glioblastoma recurrence.

Tumour-neuron interactions and malignant synapse formation drive glioblastoma progression, recurrence and neurological dysfunction, but systemic inhibition of synaptic signalling causes unacceptable neurotoxicity. Here we defined the spatial and molecular determinants of malignant synapses by analysing intact human gli...

Zhi Li, Zhao-Zhe Hao, Yi-He Zhang et al. · 0 citations
Open access Sep 2026

Epstein-Barr virus gp350 neutralizing epitopes define distinct sites of vulnerability.

Epstein-Barr virus (EBV) is a widespread human herpesvirus linked to several malignancies, yet no vaccine has been approved. Its major surface glycoprotein, gp350, mediates attachment to B cells via CR2 binding, but gp350-based vaccines have shown limited protection, raising questions about its neutralizing epitopes an...

Ge-Xin Zhao, Peng-Lin Li, Bo-Yu Yuan et al. · 0 citations

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