Review
Open access
Aug 2026
Brain insulin resistance as a driver of proteinopathy in neurodegeneration: from cell-type-specific mechanisms to targeted therapeutics
Neurodegenerative diseases are increasingly linked to systemic metabolic dysfunction, with brain insulin resistance (BIR) positioned as a central mediator. Yet translating this insight into effective therapies has proven remarkably difficult. This review argues that BIR-driven neurodegeneration should be interpreted at...
Man Xiang, Si-Yu Cao, Xue-Heng Sun et al.
· Translational Neurodegenerat... · 0 citations