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Sponsored Artificial Intelligence: A Modern Approach, Global Edition Artificial Intelligence: A Modern Approach, Global Edition

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Jing-Wen Zhao

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Review Open access Sep 2026

Acupuncture Modulation of the Microbiota–Gut–Brain Axis in Major Depressive Disorder: Integrative Mechanisms, Emerging Evidence, and Future Therapeutic Perspectives

Abstract Major depressive disorder (MDD) is a prevalent and disabling psychiatric condition. Its pathophysiology extends beyond monoamine deficiency to encompass systemic dysregulation of the gut-brain axis—a bidirectional network integrating neural, immune, endocrine, and microbial signals. Accumulating evidence indic...

Jing-Wen Zhang, Lin-Jing Wang, Shuai Shi et al. · 0 citations

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