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Oct 2026

Multilevel metabolic engineering of Shewanella oneidensis as a heme-tolerant host for efficient porphyrin production.

This work demonstrates an integrated metabolic engineering strategy combining pathway reconstruction, physiological stress mitigation, model-guided target selection, and multilevel expression balancing for developing S. oneidensis as a porphyrin-producing cell factory.

Dan Sun, Jie Wu, Ru-Li He et al. · 0 citations
Open access Sep 2026

Biosurfactants direct the evolutionary dynamics of surface-associated microbial systems

Surface-associated microbial systems experience spatial constraints that can intensify stochastic lineage loss through genetic drift and alter how natural selection acts on competing lineages. A key feature of these systems is that steep resource gradients typically confine growth to a narrow band of cells located at t...

Chu-Jin Ruan, Bi-Jing Xiong, Deepthi P. Vinod et al. · 0 citations

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