Author

Jing Xiong

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Jul 2026

PIAS1-mediated GSK3β SUMOylation exacerbates tauopathy and cognitive deficits in Alzheimer's disease models.

A novel PIAS1-GSK3β signaling axis in tauopathy and a cell-permeable blocking peptide designed to disrupt the PIAS1-GSK3β interaction are uncovered and provide a promising targeted therapeutic strategy for Alzheimer's disease.

You-Lan Qiu, Suo Wu, Yi Zhong et al. · Molecular Psychiatry · 1 citation