Author

Jing Yang

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Open access Aug 2026

Targeting the Medial Prefrontal Cortex with Transcranial Focused Ultrasound Alleviates Adolescent Sleep-Deprivation-Induced Persistent Postsurgical Pain in Adulthood

Adolescent sleep deprivation (SD) increases latent vulnerability to pain, a major risk factor for persistent postsurgical pain (PPSP) in adulthood, yet the underlying mechanisms remain unclear. Given the limitations of current pharmacological treatments, noninvasive transcranial focused ultrasound (TFUS) offers a promi...

Jing Yang, Hang-Yue Bo, Pin Lv et al. · Research · 0 citations

Open access Sep 2026

Locus coeruleus-spinal noradrenergic signaling drives sleep deprivation-induced hyperalgesia via astrocytic GAT-3.

Sleep deprivation is a prevalent health problem that amplifies pain and prolongs recovery after tissue injury, yet the neural and astrocytic mechanisms underlying this relationship remain poorly defined. Here, we demonstrate that sleep deprivation activates locus coeruleus noradrenergic neurons and elevates spinal nore...

Jia-Cheng Yu, Lu Han, Mei Li et al. · Neurobiology of Disease · 0 citations