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Author

Jing-Yi Wu

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Aug 2026

EIF2AK2 inhibits type I interferon production by inhibiting RIG-I activation and disrupting mitochondria function via recruiting VAMP8 and p-MLKL.

It is demonstrated that viral infection induced elevated expression of Eukaryotic translation initiation factor 2 alpha kinase 2 (EIF2AK2), which is an interferon-stimulated gene (ISG) with unclear role in the innate immunity, and its potential as a therapeutic target for controlling dysregulated IFN-I responses is sug...

Qin Chen, Jing-Yi Wu, Fang-Bin Huang et al. · 0 citations

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