Author

Jing-Yi Xu

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Open access Oct 2026

SEC Mediates m6A Deposition and Transcription Pause Release to Drive Cell Identity Transition

ABSTRACT Background: Induced pluripotent stem cell (iPSC) reprogramming and embryonic stem cell (ESC) differentiation represent opposite models of cell identity transition, yet their regulatory mechanisms remain incompletely understood. Here, we identify the Super Elongation Complex (SEC), the most pivotal regulators o...

Zhi-Jing Zhang, Jing-Yi Xu, Yong-Hong Wu et al. · Advancement of science · 0 citations

Open access Sep 2026

Daxx depletion remodels silent rDNA chromatin and increases UBF-bound transcriptional potential.

Ribosomal DNA (rDNA) repeats are regulated by DNA methylation, histone modifications, nucleosome occupancy, and nucleolar organization. Here, we used a data-driven ChIP-seq background-subtraction strategy to re-examine epigenetic profiles at rDNA repeats and found that Daxx and Atrx are preferentially enriched in the p...

Yan-Shuang Wu, Jing-Yi Xu, Xing-Wei Huang et al. · Biochemical and Biophysical... · 0 citations

Sep 2026

From molecular binding to mouthfeel: Oil saturation controls oral lubrication through interfacial protein films.

The oily mouthfeel is a critical sensory governed by the lubrication of saliva emulsions during oral processing, but the molecular mechanisms remain unclear. This study investigated this mechanism by using a saturated oil (Medium-chain triglyceride, MCT), a monounsaturated corn oil (CO), and a polyunsaturated linseed o...

Ruo-Jie Zhang, Jing-Yi Xu, Lei Dai et al. · Food Chemistry · 0 citations