Biodegradable Biomimetic Nanoplatform Orchestrating an Oxygen-Lactate Cascade to Enhance Photothermal Immunotherapy.
This work demonstrates a synergistic metabolic-photothermal immunotherapy strategy for efficient and long-lasting cancer treatment and achieves strong tumor accumulation, effective photothermal ablation, and combined with lactate depletion, complete tumor eradication without systemic toxicity.