Author

Jing-Yu Chen

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Open access Nov 2026

KLHL6 drives colorectal cancer liver metastasis through ubiquitin-mediated degradation of MBD2 that triggers CLDN4 activation

Liver metastasis is the leading cause of death among patients with colorectal cancer (CRC) and remains a major clinical challenge because durable therapeutic options are limited. Metastatic progression depends on extensive transcriptional plasticity, yet how epigenetically silenced prometastatic genes are reactiv...

Wen-Wen Chen, Xiao-Yun Yang, Guochun Lou et al. · Journal of Experimental &amp... · 0 citations

Open access Aug 2026

Multi‐Omics Integration Identifies a CDH3‐Associated Malignant Epithelial State and Immunosuppressive Niche to Predict Prognosis in Thymic Epithelial Tumors

CDH3 is defined as a biomarker and therapeutic target linking malignant epithelial plasticity to immunosuppressive niche formation and adverse clinical behavior in TETs.

Yuntao Feng, Jing-Yu Chen, Lang Xia et al. · Advancement of science · 0 citations