Review
Open access
Aug 2026
FOXP3 Stability-Adaptation Paradox: Reshaping Treg-Based Therapies for Intestinal Diseases
Regulatory T cells (Tregs) maintain intestinal immune homeostasis, but their therapeutic potential is constrained by a fundamental paradox: the same plasticity that enables tissue repair renders FOXP3 vulnerable to degradation in chronic inflammation. Mechanistically, microbial metabolites (short-chain fatty acids, bil...
Yu-Shu Ren, Xiao-Hui Liu, Bo-Ya Wang et al.
· International Journal on Bio... · 0 citations