Development and Protective Evaluation of an O18–CRM197 Glycoconjugate Candidate Preparation Against APEC O18 Challenge in SPF Chickens
Avian pathogenic Escherichia coli (APEC) is an important cause of colibacillosis in poultry, and increasing antimicrobial resistance has highlighted the need for alternative preventive strategies. This study aimed to develop an O18-cross-reacting material 197 (O18–CRM197) glycoconjugate vaccine candidate using an Esche...