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Sponsored Artificial Intelligence: A Modern Approach, Global Edition Artificial Intelligence: A Modern Approach, Global Edition

Author

Jing Zhang

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Sep 2026

Discovery of FM-604, a Benzyl-Substituted Pyrimidinedione PPO Inhibitor with Potent Postemergence Herbicidal Activity

Protoporphyrinogen IX oxidase (PPO) is a validated target for fast-acting herbicides. To identify low-dose PPO-inhibiting leads, 41 benzyl-substituted pyrimidinedione derivatives were designed by side-chain optimization of epyrifenacil and synthesized. In greenhouse postemergence screening, FM-604 provided 100% contr...

Jia-Lin Ye, Hong-Yan Pei, Dong-Dong Liu et al. · 0 citations
Aug 2026

Scaffold Hopping-Driven Discovery of Novel Thioether Fungicides: Design, SAR, and Computational Insights into Structure-Activity Relationships.

Sixty novel 5-(trifluoromethyl)-1,2,4-oxadiazole derivatives were designed by scaffold hopping from the diamide lead 6n and synthesized to examine ether, thioether, and sulfoxide linkers. Greenhouse assays against Phakopsora pachyrhizi identified FM-12818 (B5) as a leading thioether derivative, with an EC50 of 0.45 mg·...

Yuan-Dong Liu, Jia-Lin Ye, Yu-Xin Huang et al. · 0 citations
Aug 2026

Discovery of FM-2665 as a Potent Arylpyrazole Insecticidal and Acaricidal Candidate: Rational Design via Pyridine Bioisosterism and Terminal Alkyl Optimization.

Sixteen novel arylpyrazole derivatives were designed using tigolaner as a scaffold reference and synthesized to examine the effects of pyridine bioisosterism and terminal alkyl modification. Among the synthesized compounds, FM-2665 (A14) showed the highest overall activity against Plutella xylostella, Tetranychus cinna...

Xiaowen Du, Dong-Dong Liu, Qingjie Bi et al. · 0 citations
Jul 2026

Novel Cyclopropyl-Uracil Derivatives as Potent Herbicides: Design, Synthesis, Activity, and Structure-Activity Relationship.

Herbicides are critical for agricultural weed management. Thirty-seven cycloalkyl-substituted pyrimidinedione derivatives were designed and synthesized via molecular hybridization to explore efficient herbicidal leads. All compounds displayed outstanding postemergence activity against broadleaf weeds, and several exhib...

Hong-Yan Pei, Jia-Lin Ye, Dong-Dong Liu et al. · 0 citations

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