Author

Jing Zhang

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Open access Sep 2026

Substrate Profiling of RNF216 Uncovers a Translation-Linked OTUD4 Regulatory Axis

Overall, the findings show that RNF216 and OTUD4 balance rates of protein synthesis and degradation and suggest GHS-related mutations in RNF216 or OTUD4 may offset this balance, triggering neurodegeneration.

Wei Wei, Ruochuan Liu, Jing Zhang et al. · bioRxiv · 0 citations