MiR-485-5p targets RGS4 to promote angiogenesis in lower limb ischemia by activating VEGFR-2/AKT/ERK1/2 signaling.
Angiogenesis is critical for post-ischemic tissue repair. Although miR-485-5p is highly expressed in vascular tissues and RGS4 regulates angiogenesis, their specific roles under hypoxia remain largely unknown. This study aimed to elucidate these functions and underlying mechanisms. Using a CoCl₂-induced hypoxic model i...