Aug 2026
TRAF4-mediated PRMT5 ubiquitination destabilizes GPX4 and promotes endothelial ferroptosis in atherosclerosis.
The results showed that TRAF4 was upregulated in atherosclerotic tissues, the public dataset, and ox-LDL-treated HCAECs and the TRAF4-PRMT5-GPX4 axis may represent a therapeutic target in AS.
Jia-Yu Wang, Jing-Jin Li, Jia Zhang et al.
· Cellular Signalling · 0 citations