Benzyl isothiocyanate alleviates endotoxin-induced uveitis in association with LOX-1 downregulation to modulate JAK2-STAT3 signaling, endoplasmic reticulum stress and apoptosis.
Uveitis is a sight-threatening inflammatory ocular disorder. Benzyl isothiocyanate (BITC) exhibits potent anti-inflammatory pharmacological activity. This research was designed to explore the therapeutic mechanism of BITC in acute uveitis (AU). We established a mouse model of endotoxin-induced uveitis (EIU) to evaluate...