Jingling Peng

Disuse-induced skeletal muscle IDO1 activation contributes to kynurenine-dependent muscle-liver crosstalk and hepatic oxidative injury.

Physical inactivity and mechanical unloading induce skeletal muscle atrophy and are associated with systemic metabolic disorders, but the molecular basis linking muscle disuse to liver injury remains unclear. Human cohort analyses (CHARLS, NHANES), a mouse hindlimb immobilization model, and multi-level in vitro systems...