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Jingsong Ruan

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Open access Aug 2026

Loss of laminin-γ1 in pericytes impairs microvascular function and cognition.

Blood-brain barrier (BBB) disruption correlates with lesion burden and cognitive dysfunction in cerebral small vessel disease (CSVD). Laminin, highly produced by pericytes in the brain, maintains BBB integrity. However, it remains unclear if laminin dysregulation contributes to the pathogenesis of CSVD. Here, we show t...

Jingsong Ruan, Ava Nasrollahi, Cecilia G. Martin et al. · 0 citations

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