Open access
Aug 2026
Metformin improves chronic rhinosinusitis with depressive-like behavior in mice by targeting TCF4 to inhibit the TLR4/NF-κB pathway
This study comprehensively links TCF4 to neuroinflammation in CRSDB, and identified TCF4 as a direct target of metformin, through which it inhibits the TLR4/NF-κB pathway and subsequent microglial activation.
Bingxi Yu, Fan-Dong Yang, Jingwen Tian et al.
· Scientific Reports · 0 citations