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Jingye Lin

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Sep 2026

Osmolytes suppress liquid‒liquid phase separation and the aggregation of Tau.

Tau liquid-liquid phase separation (LLPS) is increasingly recognized as an early event that promotes pathological aggregation in Alzheimer's disease and other tauopathies. Osmolytes are natural chemical chaperones that stabilize protein conformations, yet their effects on Tau phase behavior remain poorly understood. He...

Jingye Lin, Zongbao Wang, Chen-Xi Liu et al. · 0 citations

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