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Sponsored Artificial Intelligence: A Modern Approach, Global Edition Artificial Intelligence: A Modern Approach, Global Edition

Author

Jinyu Lu

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Jul 2026

Abstract A055: Integrative epigenomic characterization of MGMT and LINE-1 methylation in diffuse gliomas and colorectal cancer: insights from rare brain tumors

Joint assessment of MGMT and LINE-1 methylation uncovers an aggressive epigenomic subtype of rare brain tumors that phenocopies CRC epigenetic features and suggest conserved epigenomic vulnerabilities exploitable by hypomethylating agents.

Jinyu Lu · 0 citations
Jul 2026

Abstract B031: Pan-cancer dissection of TERT promoter mutations in rare gliomas and colorectal cancer: shared vulnerabilities and therapeutic implications

GABP is established as a shared vulnerability in TERTp-mutant rare gliomas and CRC, nominating this axis for pan-cancer therapeutic development and targeting the non-coding oncogenic pathway downstream of TERTp may bypass the limitations of direct telomerase inhibition.

Jinyu Lu · 0 citations

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