Author

Jisun Lee

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Open access Jul 2026

Optimized Lipid Nanoparticles with Tail‐Modified Ionizable Lipids for Safer mRNA Delivery

ABSTRACT Despite the growing importance of lipid nanoparticles (LNPs) in mRNA therapeutics, current ionizable lipids, which comprise an ionizable head group, a linker, and hydrophobic tails that collectively govern the delivery behavior, exhibit dose‐limiting toxicity and suboptimal efficiency. Hydrophobic tail chemist...

Seo-Hyeon Bae, Jisun Lee, J. Ahn et al. · Advancement of science · 0 citations

Review Open access Aug 2026

Take Five: harmonization in personalized cancer vaccines for cancer immunotherapy

It is proposed that the future maturation of PCVs will require a coordinated process across five interconnected dimensions: advances in neoantigen prediction technologies, rapid delivery of PCVs to patients, an increase in anticancer efficacy through combination therapy strategies, establishment of cost-effective manuf...

Seongje Cho, Jisun Lee, Young-Min Lee et al. · Experimental and Molecular M... · 0 citations