Development And Optimization Of Baicalin Nanoparticle Loaded Oral Hydrogel For Colon-Targeted Therapy In Inflammatory Bowel Disease
Objectives: To develop and optimize baicalin-loaded Eudragit S100-coated PLGA nanoparticles using Soluplus® as a novel steric stabilizer and incorporate the optimized batch into a Carbopol 974P NF oral hydrogel for pH-responsive colon-targeted delivery in inflammatory bowel disease, addressing the biopharmaceutical lim...