Author

Jiucun Wang

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Open access Oct 2026

Spectral-Distribution Uncertainty Modeling for Robust Cross-Domain Medical Image Segmentation

Domain generalization (DG) for medical image segmentation is commonly approached by simulating domain shifts through deterministic image transformations or feature perturbations. However, such methods implicitly assume that unseen domains can be approximated by predefined appearance variations. In this work, we challen...

Chao Xin, Zhi-Xiong Chen, Ze-Yu Huang et al. · Bioengineering · 0 citations

Open access Aug 2026

A compact five-gene immuno-fibrotic profile distinguishing systemic sclerosis subtypes with PXDN validated as a fibrosis-associated target

The integrative analysis identifies a concise immunofibrotic gene signature that robustly distinguishes SSc and its major subtypes, highlighting a potential nexus of immune-stromal interactions that may underlie disease heterogeneity, offering candidate biomarkers for molecular stratification and therapeutic targeting.

Xiang-Yue Zhao, Ke-Jian Hu, Yin-Zhi Cui et al. · Frontiers in Immunology · 0 citations

Open access Aug 2026

Deep Immunophenotyping Unravels the Double Negative T cells and PD-1-Mediated Inflammatory Exhaustion in Ankylosing Spondylitis

A detailed functional immune map of biologic-naïve active AS is provided, offering novel mechanistic insights and identifying candidate biomarkers for precision intervention.

Lu Bai, Jian Gao, Yunyun Xu et al. · Phenomics · 0 citations