Jiun-I Lai

NeoGen-BC: A synergistic framework combining generative protein language models and multi-window deep learning for designing shared neoantigens in breast cancer.

Breast cancer, particularly hormone receptor-positive (HR+) and triple-negative (TNBC) subtypes, is often immunologically "cold," limiting immunotherapy efficacy. Neoantigen-based vaccines hold promise but face challenges from inaccurate identification and overreliance on HLA binding affinity, which poorly captures tru...