Deciphering the conformational and functional alterations of α-glucosidase induced by emerging tire-derived contaminants 6PPD and 6PPD-quinone.
N-(1, 3-dimethylbutyl)-N'-phenyl-p-phenylenediamine (6PPD) and its transformation product 6PPD-quinone are emerging tire-derived contaminants with disruptive effects on glucose metabolism. Given that α-glucosidase is key to blood glucose homeostasis, this study used multivariate methods to explore how 6PPD and 6PPD-qui...