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Author

Jizhong Zou

2 papers indexed here

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Open access Sep 2026

Cellular modifiers of TDP-43 phase transition and cytoplasmic aggregation

RNA-binding protein TAR DNA-binding protein 43 (TDP-43) can form liquid-like nuclear assemblies whose phase behavior is thought to influence its aggregation propensity and neurotoxic activity. The mechanisms that govern the liquid-to-solid phase transition of TDP-43 remain poorly defined. Here, we combined chemical and...

Natalie Chin, Qi Zhang, Ji-Zhong Zou et al. · 0 citations
Open access Aug 2026

Establishment of human induced pluripotent stem cell lines and isogenic gene-corrected controls from three patients with prolidase deficiency.

Prolidase deficiency is an autosomal recessive inborn error of metabolism caused by pathogenic variants in the PEPD gene. To date, close to 200 patients have been reported worldwide with a poorly understood pathomechanism. The PEPD gene encodes an enzyme that is involved in the final steps of collagen degradation. Urin...

R. Suri, Kevin Emmerich, Sahana Manohar-Sindhu et al. · 0 citations

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