The Transmembrane Envelope Protein of Porcine Endogenous Retroviruses Modulates Cytokine Release and Gene Expression in Human Immune Cells
Porcine endogenous retroviruses (PERVs), their transmembrane envelope protein p15E and peptides corresponding to a domain in p15E that is highly conserved among retroviruses, the immunosuppressive (isu) domain, demonstrated immunosuppressive properties. They inhibited in vitro immune reactions, and induced release of I...