João Carneiro

Decoding Voltage-Gated Sodium Channels Structure: Molecular Mechanisms Linking Architecture, Function, and Disease.

Voltage-gated sodium (NaV) channels are critical transmembrane proteins responsible for the initiation and propagation of electrical signals in excitable tissues. They consist of a large α subunit and auxiliary β subunits. Together, the voltage sensing, ion selectivity, and rapid gating transitions regulate neuronal, m...