Author

João Conde

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Open access Jul 2026

In Vivo Multimodal Self-Immolative Prodrug Nanomicelle-Hydrogel Modulate Key Intratumoral and Metastatic Genomic Signaling Pathways in Pancreatic Cancer

The data suggest that encapsulation of PTX and GEM in these micelles embedded within a hydrogel could alter the pharmacokinetics and pharmacodynamics of these agents, thereby modulating their interactions with cellular targets, thus optimizing the clinical outcomes.

João M J M Ravasco, Jhenifer Oliveira, João Conniot et al. · ACS nano medicine · 0 citations

Open access Aug 2026

Procyanidin C1 activates Nrf2/HO-1 to preserve in vivo mitochondrial homeostasis and counter chondrocyte senescence in osteoarthritis

Findings establish a mechanistic link between PCC1, Nrf2/HO-1 activation and chondrocyte mitochondrial homoeostasis in osteoarthritis, and support Nrf2-directed senotherapies as a regenerative strategy to slow OA progression.

Yubiao Zhang, Mao Chen, Wenxiang Cai et al. · Cell Death & Disease · 1 citation