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Author

João F. Mano

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Open access Aug 2026

Remodeling of lipid metabolism orchestrates human adipose-derived mesenchymal stem cells osteodifferentiation.

Mesenchymal stem cell (MSC) osteodifferentiation involves adaptations of lipid metabolism but the specific regulatory roles of lipid species remain underexplored. We use a global metabolomics approach, comprising LC-MS lipidomics and NMR metabotolomics, to identify mechanistic features of human adipose-derived MSC (hAM...

Daniela S C Bispo, Jennifer H. Haggarty, Inês C. R. Graça et al. · 0 citations
Open access Aug 2026

A one-step volumetric biofabrication platform for complex hydrogel-based hollow biomaterials

Rotational molding (RM) is a widely used industrial process for producing hollow polymeric structures, yet it remains largely unexplored for biomaterials fabrication. Here, a low-cost 3D-printed biofabrication platform is introduced that adapts the general concept of RM to generate tunable hollow constructs with high s...

Luís P. G. Monteiro, João M. M. Rodrigues, João F. Mano · 0 citations

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