Open access
Jul 2026
Embryonic TGF-β signaling imposes persistent changes to HSPC clonality and inflammatory landscape
Transient developmental signaling perturbations reshape hematopoietic trajectories produce sustained effects on hematopoietic and immune function into adulthood, including diminished inflammatory gene expression, reduced clonal complexity, and impaired regenerative capacity.
Marta Mastrogiovanni, Anastasia Nizhnik, Joaquín Cantón-Sandoval et al.
· bioRxiv · 0 citations