Amyloid beta (Aβ) deposition and tau accumulation are neuropathological hallmarks of Alzheimer’s disease (AD). While Aβ deposits present with a wide morphological variety, a comprehensive, cross-regional overview of Aβ plaque composition in AD and associations with clinicopathological traits are missing. In this study,...
Antonia Neubauer, Paul L. C. Feyen, S. Pekrun et al.· Acta Neuropathologica· 0 citations
Tau aggregation, a defining feature of tauopathies, commonly appears as neuropil threads within neurites including axons. However, the affected neuronal populations and the spatial organization of axonal vulnerability remain poorly defined. Here, following identification of Tau accumulation in parvalbumin (PV) interneu...
Paul L. C. Feyen, Yu-Xiao Zhang, Theresa Niedermeier et al.· bioRxiv· 0 citations
A reproducible human three-dimensional brain tissue model with neurons, astrocytes and microglia, replicating in-vivo-like maturation and enabling the study of Alzheimer’s disease-relevant perturbations and drug responses is developed.
Julien Klimmt, Carolina Cardoso Gonçalves, J. V. Montgomery et al.· Nature Neuroscience· 1 citation
Background Progressive supranuclear palsy (PSP) is a primary tauopathy defined by the accumulation of 4R tau isoforms in neurons, oligodendrocytes and astrocytes. Despite evidence of genetic susceptibility operating through glial cell types, it remains poorly understood how cell type-specific epigenetic-transcriptional...
N. Briel, Viktoria C. Ruf, Paul L. C. Feyen et al.· bioRxiv· 0 citations
It is shown that early complement associated pruning of inhibitory synapses precedes overt α-synuclein aggregation and neuronal loss in prodromal synucleinopathy, indicating disease-context dependent relationships between αSyn pathology and neurodegeneration.
Svenja-Lotta Rumpf, Felix L. Strübing, Karsten Nalbach et al.· Nature Communications· 0 citations
We use cookies to run the site and, with your consent, for analytics and to show ads.
See our Cookie Policy.
