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Open access Aug 2026

A Modular Synthesis of C5‐Sulfenyl Thiazoles via an Intermolecular Pummerer Rearrangement: An Underexplored Scaffold for Medicinal Chemistry

ABSTRACT The introduction of sulfur substituents to heterocyclic cores in fragments and drugs is hugely advantageous, improving key pharmacokinetic properties, providing additional vectors for synthetic elaboration, and potentially enhancing binding affinities. Despite this potential and their prevalence in drug discov...

Joe L Smy, Theo C Webb, Barnaby W. Greenland et al. · 0 citations

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