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Joel A. Paulson

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#machine learning Preprint Oct 2026

Isotropic Gaussian Processes Improve Vanilla Bayesian Optimization in High Dimensions

High-dimensional Bayesian optimization (BO) often fits Gaussian process (GP) surrogates from far fewer observations than input dimensions. Modern Vanilla BO can perform well in this regime with dimension-aware priors, initialization, and acquisition optimization, but it typically retains automatic relevance determinati...

Wei-Ting Tang, Madhav R. Muthyala, Joel A. Paulson · 0 citations
Open access Jul 2026

Experimentally Tuned Protein-RNA Rosetta Score Function using Bayesian Optimization

This work proposes an experimentally tuned protein-RNA score function that can be directly implemented into ROSETTA and establishes a framework to efficiently fine-tune ROSETTA score functions for any protein-class interaction using Bayesian Optimization.

Joe Bailey, Nathan Phan, Søren C. Spina et al. · 0 citations

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