Open access
Sep 2026
Analysis of host and viral nascent and steady-state RNA levels in a human neuronal model of herpes simplex virus 1 infection
The results indicate that viral gene transcription initiation does not correlate with viral transcript abundance during the latent phase, and suggest that blocks to RNA polymerase processivity and other components of the RNA life cycle likely contribute to maintenance of latency in LUHMES neurons.
Claire H. Birkenheuer, Terri G. Edwards, David C. Bloom et al.
· PLoS Pathogens · 0 citations