Parkinson's disease (PD) and related -synucleinopathies are defined by the spread of Lewy body (LB) pathology across vulnerable brain regions, yet how substantia nigra (SN) myeloid cells respond remains unresolved. Using SOX10-based oligodendrocyte depletion and CD11b-based myeloid enrichment, we profiled 169,799 brain...
Raphael Kübler, Daniele Mattei, J. O. Narcís et al.· medRxiv· 0 citations
It is shown that APOE4 pericytes transition into myofibroblasts that secrete fibronectin, which promotes vascular amyloid accumulation in AD, and elevated TGF-β signaling is identified as the driver of this pericyte-to-myofibroblast transition.
B. Schuldt, Dominic Haworth-Staines, Andrea Perez-Arevalo et al.· Cell· 0 citations
An iPSC-based 3D model that integrates neurons, glia, myelin, and cerebrovascular cells into a human brain-like tissue (“miBrain”) is developed and establishes a robust model for investigating protein inclusions in human iPSC-derived brain tissue.
Louise A. Mesentier-Louro, Camille Goldman, Sebastian Gaese et al.· Cell Stem Cell· 2 citations
Iterative Mapping of proteoforms provides insights into proteoform complexity at the single-molecule level, with implications for understanding protein regulation in neurodegenerative diseases and beyond.
James Joly, V. Budamagunta, Zheng-Jian Zhang et al.· Nature Methods· 1 citation
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