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Johannes Broichhagen

2 papers indexed here

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Open access Sep 2026

Configurational diversity of metabotropic glutamate receptor complexes with beta-arrestins

Beta-arrestins (β-arrs) are cytosolic proteins which mediate G protein-coupled receptor (GPCR) desensitization, endocytosis, and signaling. Despite the widespread physiological roles of β-arr coupling, the molecular basis of GPCR/β-arr interaction has been studied primarily in monomeric family A GPCRs. Here we develop...

Dagan C. Marx, Alberto J. Gonzalez-Hernandez, Joon Lee et al. · 1 citation
Open access Aug 2026

Emergence of new function through evolutionary divergence of an intrinsically disordered region

Intrinsically disordered regions (IDRs) are major drivers of protein functional diversification, yet the molecular features that enable the emergence of new functions within disordered sequences remain poorly understood. FCHO1 and FCHO2 are paralogous pioneer proteins of clathrin-mediated endocytosis that share a conse...

Carlos A. Elena-Real, Antonia M. Körber, Blaise Gatin-Fraudet et al. · 0 citations

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