Author

J. Herrmann

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Open access Oct 2026

A selectivity filter in Tim17 mediates intramitochondrial protein sorting

Mitochondria import hundreds of proteins into the matrix and the inner membrane (IM). The translocase of the IM of mitochondria (TIM23 complex) sorts these proteins using topogenic signals in their structure and directs them into the matrix or inserts them into the IM. How these signals are deciphered is unknown. Her...

Annika Egeler, Sanjoy Paul, Rosario Valenti et al. · Nature Communications · 0 citations

Open access Aug 2026

Succinate and its carrier Sfc1 mediate metabolic control of mitochondrial protein import by the TIM23 translocase.

The findings show that metabolites can regulate mitochondrial import and adjust the segregation of key metabolic enzymes between the cytosol and mitochondria.

K. Das, Rituparna Samanta, Tamar Ziv et al. · Cell Reports · 0 citations

Open access Aug 2026

Presequences of non-imported mitochondrial proteins serve as quality control elements in the cytosol

This study comprehensively elucidated the role of the presequence and the mature part of mitochondrial precursors in the cytosol, by use of a cytosol-targeted MPP which prematurely processed mitochondrial precursors.

Svenja Lenhard, Annika Nutz, Gülsah Göktas et al. · bioRxiv · 0 citations