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Author

John A. Capra

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Open access Sep 2026

Identifying human-specific transcription factor binding site gains and losses that contribute to human-specific phenotypes

Identifying the genetic changes responsible for human-specific traits remains a central challenge in evolutionary genomics. Although thousands of modern human-specific variants have been identified through comparisons with Neanderthal, Denisovan, and great ape genomes, the phenotypic consequences of most of these chang...

Manuel Ferrando-Bernal, John A. Capra · 0 citations
Open access Aug 2026

Methylation clocks fail to generalize across genetically admixed individuals

Epigenetic aging clocks based on DNA methylation patterns across the genome have emerged as a potential biomarker for risk of age-related diseases, like Alzheimer’s disease (AD), and environmental and social stressors. However, methylation clocks have not been comprehensively validated in genetically diverse individual...

Sebastián Cruz-González, Ogechukwu Okpala, Esther Gu et al. · 0 citations
Open access Jul 2026

EXCAVATE-HT: A Bioinformatic Pipeline to Identify Targetable Genomic Variants for Allele-Specific Editing

ExCAVATE-HT (EXtracting Common Allelic VAriants for Targeted Editing in High-Throughput) a bioinformatic tool that mines population variant data to generate CRISPR libraries targeting genomic loci for allele-specific editing is introduced.

Akshita G Saxena, Grace D. Ramey, John A. Capra et al. · 0 citations

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