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John B. Linehan

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Sep 2026

Multiscale temporal tuning of the force generation complex governs cortical microtubule interactions during the first mitotic division in C. elegans.

Dynein is an essential microtubule motor whose many roles in mitosis complicate efforts to resolve its spatiotemporally dynamic regulation. We previously established a method to classify single particles of the conserved cortical force generation complex (dynein-LIN-5NuMA-GPR-1/2LGN-GαGαi), as free or interacting with...

G. A. Edwards, John B. Linehan, A. Maddox et al. · 0 citations

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