Open access
Aug 2026
Genome evolution during the domestication of an antibiotic-producing Streptomyces strain
The domestication of Streptomyces species for antibiotic production involves long-term, iterative mutagenesis and selection, yet the genomic changes driving enhanced production remain unclear. Analysis of five strains from an industrial lineage of Streptomyces clavuligerus using comparative genomics, transcriptomics an...
John T. Munnoch, D. Larcombe, Rebecca E. McHugh et al.
· bioRxiv · 0 citations