Author

John C. Chaput

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Open access Sep 2026

Chiral-4′-Methyl-α‑(l)‑Threofuranosyl Nucleic Acids: Synthesis, Structure, Binding Affinity, Nuclease Resistance, and Polymerase Recognition

α-(l)-(3′–2′)-Threofuranosyl nucleic acid (TNA) cross-pairs with DNA and RNA and is not degraded by nucleases and thus has potential for use in diagnostics and therapeutics based on nucleic acids. Here, we describe the synthesis of 15 building blocks of chiral 4′-(R)- and 15 building blocks of chiral (S)-methyl-α-(l)-t...

Atsushi Mikami, Dhrubajyoti Datta, Jayanta Kundu et al. · Journal of the American Chem... · 0 citations

Open access Aug 2026

Dynamism and evolvability in nucleic acid enzymes

It is proposed that threose nucleic acid (TNA), a genetic polymer that is more conformationally restricted than DNA, may be evolutionarily constrained by its preorganized backbone, and the rigid TNA backbone limits adaptability.

Erica Kim Man Lee, John C. Chaput · Nature Communications · 0 citations