Author

John D. Carpten

3 papers indexed here

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Open access Oct 2026

Multi-omics analysis of high-grade serous ovarian cancers reveals heterogeneity and distinct immunological patterns based upon clinico-genomic status

A spatially resolved framework identifies BRCA-associated immune transcriptional patterns in HGSOC and provides a basis for future mechanistic validation, and support a model in which BRCA mutation status is associated with functional differences within broadly conserved spatial regions, rather than extensive reorganiz...

Jing Qian, R. Bassiouni, Yu-Xin Jin et al. · PLoS Genetics · 0 citations

Open access Oct 2026

African Genetic Similarity Is Associated with Reduced Inflammation and Enhanced Adaptive Immunity in Multiple Myeloma.

The bone marrow immune microenvironment (BMME) is a critical factor in multiple myeloma (MM) pathogenesis. Despite higher incidence of MM among self-identified African Americans, the relationship between African genetic similarity and the BMME remains unclear. We present the largest analysis to date assessing the impac...

William C. Pilcher, Hong-Wei Tang, Katherine Ferguson et al. · Blood · 0 citations

Oct 2026

Abstract C126: Integrated whole genome and transcriptome analyses reveal ancestry-associated molecular features of breast cancer

Women of African ancestry experience disproportionately aggressive breast cancer (BC) and poorer survival yet remain substantially underrepresented in cancer genomic studies. Consequently, the contribution of inherited genetic ancestry to breast tumor biology remains poorly understood. To address this gap, we lev...

Rachel Martini, William Hooper, Timothy R. Chu et al. · Cancer Epidemiology, Biomark... · 0 citations